Kym (Anne Hathaway) is released from rehab for a few days so she can go home to attend the wedding of her sister Rachel (Rosemarie DeWitt). At home, the atmosphere is strained between Kym and her family members as they struggle to reconcile themselves with her past and present. Kym's father shows intense concern for her well-being and whereabouts, which Kym interprets as mistrust. She also resents her sister's choice of her best friend Emma (Anisa George), rather than Kym, to be her maid of honor. Rachel, for her part, resents the attention her sister's addiction is drawing away from her wedding, a resentment that comes to a head at the rehearsal dinner, where Kym, amid toasts from friends and family, takes the microphone to offer an apology for her past actions, as part of her twelve-step program.
Underlying the family's dynamic is a tragedy that occurred many years previously, which Kym retells at a Narcotics Anonymous meeting. As a teenager, Kym was responsible for the death of her young brother Ethan, who was left in her care one day despite her being high at the time. Driving home from a nearby park, Kym had lost control of the car, driving over a bridge and into a lake, where her brother drowned.
The day before the wedding, as Rachel, Kym, and the other bridesmaids are getting their hair done, Kym is approached by a man who she knew in an earlier stint in rehab. He thanks her for the strength she gave him through a story about her childhood sexual abuse at the hands of an uncle and caring for her sister, who was anorexic. Rachel, hearing this, storms out. The story, it turns out, was all a lie — an apparent attempt by Kym to evade responsibility for her addiction. The sisters' fight comes to a head later that night, leading Kym to escape to her mother's house. However, she finds no respite there, as a fight with her mother comes to blows. She runs off again, this time intentionally crashing a car into a giant rock, and spends the night in the car.
The next morning, the day of the wedding, Kym is awoken by police. After passing a sobriety test, she gets a ride home. She makes her way to Rachel's room, as Rachel prepares for the wedding. Seeing Kym's bruised face, the anger of the previous night vanishes, and Rachel tenderly bathes and dresses Kym.
Amid a festive Indian theme, Rachel and her fiancé are wed. Kym is the maid of honor, and is overcome with emotion as the couple exchange their vows. Kym tries to enjoy herself throughout the wedding reception but continues to feel out of place and is nagged by the unresolved dispute with her mother. Ultimately, her mother leaves the party early, despite Rachel's effort to bring the two together, and the gulf between Kym and her mother is left unreconciled....
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